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a16z crypto released data showing that the trading volume of prediction markets has set a historical high for the third consecutive week, with the total market trading volume reaching $14.4 billion for the first time last week, a significant increase from about $5-6 billion at the beginning of the year, while the previous historical high of about $10 billion was only refreshed a week ago.In addition, the open interest rose to $1.6 billion, setting a historical high for the third consecutive week, indicating that the speed of new positions being opened continues to outpace the pace of positions being closed, leading to an expanding capital risk exposure. Among them, the growth in non-sports markets is particularly significant, covering areas such as macroeconomics and emergencies, with a total trading volume of $3.6 billion last week on Kalshi and Polymarket, surpassing the total scale of all categories in the prediction market last year.

AI company Mirendil announced the completion of a $200 million seed round financing, led by a16z and Kleiner Perkins, with participation from institutions like NVIDIA.The founding team consists of 20 researchers and engineers from leading institutions such as Anthropic, xAI, Google DeepMind, and OpenAI. a16z stated that Mirendil is building a system that can assist anyone in AI research and development, training models with expertise in cutting-edge AI research fields, and creating products around it to form a self-sustaining system that can autonomously address engineering problems and continuously advance without human intervention.

According to official news, the computing power market infrastructure company Ornn announced the completion of a $33 million seed round financing, led by a16z Crypto, with participation from Galaxy Ventures, Nordstar, and SV Angel, while Vine Ventures, Crucible Capital, Link Ventures, and Box Group continue to support.Ornn stated that a mature commodity market first requires reliable pricing data, which leads to price discovery, and price discovery then supports risk transfer, which in turn enables more efficient capacity allocation. The OCPI it launched is a transaction-based computing power index aimed at providing a unified and trustworthy price benchmark for settlement in the computing power market. Partners like ICE can promote risk transfer by directly referencing OCPI's futures and options contracts.Additionally, Ornn announced the launch of Ornn Compute, a physical capacity layer for the computing power market that can aggregate dedicated GPU capacity from multiple neoclouds onto a single platform, providing a unified access process, a secondary transfer market, and on-demand subleasing capabilities. Operators can obtain diversified demand from multiple tenants through a single underwriting contract, while buyers can view the sites, hardware configurations, and terms of the reserved clusters. This platform will make dedicated GPU capacity a liquid asset and allow previously idle capacity to be utilized.

According to monitoring by Onchain Lens, a16z associated wallets have withdrawn 12,780 ETH (21.21 million USD) from Binance again, bringing the total withdrawal to 25,560 ETH (42.3 million USD), and then transferred the funds to a new wallet.

According to Onchain Lens monitoring, a wallet suspected to be related to a16z (0xb5E4...c24e) withdrew 12,780 ETH from Binance, worth 21.22 million USD.

a16z crypto Paul Cafiero stated that the technology and cryptocurrency industries are entering the "Show Me" era, where the previous model of gaining market recognition through vision, white papers, tokens, and team backgrounds is failing. With regulatory scrutiny, incidents involving bad actors in the industry, the large-scale entry of traditional financial institutions, and the rapid deployment of AI products, the external audience's tolerance for "stories" has significantly decreased.He believes that after institutions like BlackRock, Fidelity, JPMorgan, and Franklin Templeton entered the cryptocurrency and tokenization space, the threshold for serious projects in the industry has been raised. Project teams now need to demonstrate real data, on-chain transaction volume, active users, revenue, retention, deployed integrations, and verifiable partnerships. He stated that in 2021, it might have been possible to impress the market with 80% vision and 20% facts, but now that ratio has reversed.

According to Cryptopolitan, the decentralized lending protocol Goldfinch, supported by a16z, announced it will gradually shut down. Last Friday, an anonymous investor, Edward Morra, publicly accused the protocol of mismanagement, leading to over $50 million in user fund losses, stating that borrower defaults and failed loan restructurings made it nearly impossible for depositors to recover their funds. Just a day after the post was published, the project announced it would enter a gradual shutdown phase.The protocol's native token GFI fell from a peak of $32.94 in January 2022 to below $0.07, a decline of 99.8%, with its market capitalization dropping from over $390 million to less than $6 million. Goldfinch was founded in 2021 by former Coinbase employees, aiming to connect crypto capital with credit enterprises overlooked by traditional banks, with a16z leading its $25 million financing in January 2022. Problems began to emerge months after the funding: the Kenyan motorcycle financing company Tugende Kenya defaulted, two underlying positions in the $2 billion loan from the U.S. credit fund Stratos nearly went to zero, and the Singapore borrower Lend East could only repay 58% of the principal. As the loan portfolio deteriorated, the protocol turned to institutional credit funds but ultimately could not turn the situation around.

According to Techfundingnews, the medical AI startup Prosper AI announced the completion of a $30 million Series A funding round, led by Andreessen Horowitz (a16z), with participation from Base10 Partners, Emergence Capital, Y Combinator, and others. After this round of financing, the company has raised a total of approximately $36.6 million.Prosper AI focuses on covering the entire patient visit process through AI voice agents, including appointment scheduling, insurance verification, communication with insurance companies, and billing processing. It has currently served over 150,000 medical institutions. The company stated that the U.S. healthcare system wastes over $450 billion annually due to administrative processes, and its AI system can handle key processes from appointment to payment on a single platform, reducing the costs for medical institutions associated with switching between different systems.It was reported that Prosper AI's revenue has grown approximately five times since the last funding round in September of last year, and it has established partnerships with large healthcare IT platforms such as Athenahealth and ImagineSoftware. Investor a16z noted that healthcare institutions are shifting from "point automation tools" to "end-to-end process automation," and Prosper's goal is to eliminate all administrative friction between patient care and payment.

a16z crypto disclosed that the weekly trading volume of prediction markets reached $10.8 billion for the first time, setting a historical record. This record growth was driven by multiple global events, including the SpaceX IPO, the US-Iran peace agreement, the NBA Finals, and the World Cup.a16z crypto pointed out that the prediction market scale has rapidly expanded over the past year. A year ago, the weekly trading volume was about $500 million, and even during active market periods, the weekly trading volume was below $1 billion. Since last fall, trading volume has steadily increased, stabilizing this spring in the range of $6 billion to $7 billion. Even during the current "low volatility week," the market scale has significantly exceeded the peak levels of a year ago, indicating that the liquidity and participation in prediction markets are continuously structurally rising.

According to on-chain analyst Yu Jin's monitoring, 12 wallets suspected to belong to a16z have transferred 24 million USDC into Hyperliquid over the past 20 hours and are currently buying HYPE through TWAP (Time-Weighted Average Price). They are the largest institutional holder of HYPE at present and one of the main drivers behind HYPE's continuous new highs in recent months: excluding the portion currently being purchased, they have transferred a total of 259 million USDC into Hyperliquid since March using over a hundred wallets to purchase and stake 4.035 million HYPE, with an average price of about 64 dollars, resulting in an unrealized profit of about 29 million dollars.

According to monitoring by Ai Yi, a16z affiliated entities have withdrawn 88,350 HYPE from major exchanges in the past half hour, worth approximately 6.4 million dollars.Since 2026, this entity has reportedly accumulated 7.335 million HYPE, totaling about 340 million dollars, with an average price of 46.46 dollars, currently showing an unrealized profit of approximately 193 million dollars.

a16z Crypto General Partner Ali Yahya stated that in the previous crypto era, DAOs (Decentralized Autonomous Organizations) were undoubtedly a failed experiment, but this may simply be due to "being born at the wrong time."Ali Yahya admitted that over the past 10 years, the industry has painfully rediscovered that "direct democracy is a bad idea," as no ordinary users are willing to wake up in the morning to adjudicate risk parameters or protocol upgrades. He emphasized that with changes in the compliance landscape, the industry will regain legitimate space for experimentation, allowing exploration of representative democracy, bicameral systems, or hybrid architectures of licensed and unlicensed systems; at the same time, AI agents can fill many management responsibilities that humans are unwilling to undertake, thus allowing DAOs to truly move towards "autonomy," with the design space for the new generation of DAOs as software being limitless.

According to Chosun Biz, Silicon Valley's top venture capital firm Andreessen Horowitz (a16z) has officially established an office in Seoul. This comes about six months after announcing its expansion plans in Asia last December. a16z stated that South Korea's global competitiveness in AI, manufacturing, defense, cryptocurrency, content, and consumer goods, along with its excellent technical talent and market acceptance, are the main reasons for choosing Seoul as its strategic base in Asia. The Seoul office will initially focus on the cryptocurrency sector, with plans to gradually expand its business scope.a16z has previously invested in global tech giants such as SpaceX, Instagram, Facebook, and Airbnb. The newly appointed a16z Head of GTM for Cryptocurrency in the Asia-Pacific region, Park Sung-mo, will be based in Seoul and will leverage his experience at Naver and the Monad Foundation to support a16z's portfolio companies entering the South Korean and Asian markets. a16z stated that it will go beyond simple investment, providing support for business growth through talent recruitment, business development, policy collaboration, media support, and building a community of partners.

a16z Crypto Operating Partner Jason Rosenthal posted on the X platform that cash flow is the moat. The best companies often establish themselves by placing themselves in the "cash flow," and cryptocurrency is the first modern technology born for this purpose. If your startup has not designed its products and business models around these principles, you will miss a great opportunity. Thanks to stablecoins, funds and value can now flow at the speed of the internet—global settlement, 24/7 uninterrupted, with end-to-end programmability.Railway companies do not make money from locomotives, but from every ton of goods that pass through the tracks; companies like Visa and Jane Street are all part of the cash flow. Cash flow combined with network effects is one of the most enduring business structures in history. There is a lot of profit margin in traditional financial services, and processes such as payments, custody, lending, foreign exchange, settlement, and market making can all be compressed. Crypto entrepreneurs have the opportunity to build the next generation of cash flow businesses that are programmable, instant, and global.This model can also be extended to computing, GPU markets, AI training data, energy, robotics, space, rare earth metals, and other fields. Founders should ask themselves: Are you in the cash flow? When the value of product activities grows tenfold, does your revenue grow accordingly? In your target market, where are the segments with the highest profit margins relative to the value created?

Marc Andreessen, co-founder of the venture capital firm a16z, published an article outlining his stance on AI regulation by the U.S. government. He stated that if so-called regulation means creating complex rules by people who do not understand the technology, suppressing innovation through layers of approval and compliance requirements, and ultimately becoming a tool for large enterprises to consolidate market positions and hinder newcomers, then he will firmly oppose such regulation.In his view, excessive regulation often leads to startups being crushed by cumbersome procedures and high compliance costs, causing innovative talent to flow to more open markets, while regulatory agencies themselves continue to expand, ultimately deviating from their original goals.Andreessen specifically criticized the regulatory mindset centered on the "precautionary principle," arguing that if this concept is amplified indefinitely, it could lead society to reject new technologies out of fear of potential risks. Many regulatory measures often arrive late, after fundamental changes in technology and industry have already occurred, making it difficult to address real issues and potentially becoming obstacles to innovative development. He also attributed the relatively lagging state of technological innovation in Europe in recent years to a culture of excessive regulation, believing that regulation should not become a moat to protect vested interests and raise market entry barriers.However, Andreessen emphasized that he does not oppose all forms of regulation. On the contrary, he supports rules that can build market trust, ensure public safety, and maintain fair competition. For example, preventing AI from faking voices to commit financial fraud, preventing deepfake content from interfering with elections, preventing technology from being used to harm vulnerable groups, and ensuring that consumers and businesses can safely use new technologies.In his view, reasonable regulation is like guardrails on a highway and a braking system in a car; it does not hinder technological progress but rather allows innovation to develop in a faster and more sustainable manner. Andreessen stated that what is truly worth pursuing is not "zero regulation" or "heavy regulation," but finding a balance between innovative vitality and social trust, which is also his unwavering stance.Previously, the U.S. government forcibly "recalled" commercial models due to jailbreak risks, leading Anthropic to take Fable 5 offline overnight and publicly protest.

a16z Crypto published an interpretation of the investment in Digital Asset, stating that the three major obstacles hindering institutional adoption of crypto technology in the past included blockchain performance, regulatory uncertainty, and privacy issues. Now, the blockchain performance issue has been largely resolved, with L1 and L2 networks meeting the scale, speed, and complexity required by institutions; the US GENIUS Act has come into effect to address regulatory issues.a16z Crypto believes that traditional public chains default to public transaction information, which facilitates verification, but institutional financial transactions need to meet requirements for selective disclosure, compliance, and multi-party collaboration. For example, when banks conduct treasury bond transactions or repurchase transactions, both parties need to share information but should not expose their positions, counterparties, and transaction sizes to all network participants. Therefore, privacy remains a core challenge for institutions entering the blockchain. Most blockchain projects attempt to make institutions adapt to the crypto system, while Digital Asset chooses to adapt crypto technology to institutional needs, and mature privacy technologies have become a key breakthrough to attract institutions to enter the market.

According to The Block, Canton developer Digital Asset has completed a $355 million financing round, led by a16z crypto, with participation from subsidiaries of the Abu Dhabi Investment Authority, Apollo Global Management, BNP Paribas, Bodhi, Castle Securities, CME Ventures, Coinbase Ventures, Greenwulf Asset Management, Hanwha Investment & Securities, HSBC, Liberty City Ventures, Optiver, Polychain, S&P Global, SBI Group, SoFi, Tradeweb, and William Blair.The company stated that after this financing round, Digital Asset has entered a profitable state. Its CEO Yuval Rooz pointed out that the financing expansion of the balance sheet not only enhances the company's financial flexibility but also allows it to more freely pursue mergers and acquisitions, engage in emerging projects, and assist partners in building on-chain financial business systems.